Remove your factory amp. You'll probably get cleaner sound from a quality Head Unit (HU). I removed mine and used the Toyota wire harness adapter that I got with my Eclipse HU from Crutchfield. I'm also running aftermarket amps and speakers, so the only wires I had to adapt to the factory wire harness were HU power, ground, illumination, antenna, and battery. I removed the speaker wires from my harness adapter since I didn't need them. You'd use them all if you're running speakers directly off the HU. If I recall, your HU wires will actually connect to two separate harness adapters, one of which I show here that includes HU controls (and usually a few speaker wires). The other adapter handles the remainder of the speaker wires from the HU. Here's what my resulting adapter looks like when I spliced the appropriate wires together with barrel connectors. The small connector end plugs into my HU and the large connector end plugs into the factory wire harness. The blue and white wire with the dangling quick disconnect fitting is the 12V lead to my amps (only needed with external amps).