If you're using Android Auto then the Entune stuff seems to disable except for a couple of things that are only available when you're parked.

I'm not an Alexa user but I can say that the Google Assistant works just as you'd expect it to when you have Android Auto running. I plug my phone in, hit the "Menu" button, then touch "Android Auto". It will start the last running nav app (or depending on if you had music playing when you turned the car off from Google Music). I was using Maps but then started using Waze. It opens right to ways and it's off and going. In the bottom corner there is a bell and assistant icon. The bell is notifications that can be played back as audio and the assistant is a manual way as opposed to "Hey Google".

Overall I'm pretty satisfied. Pretty much the reason I went for a 2020 instead of a '19. The price to keep the nav updated is not cheap. I know it's silly to complain about but in our '13 Odyssey it is completely out of date and is sometimes confused when we're on roads that have been added since we purchased it. Some will reply that "it's nice to have it when you don't have cell signal and you're off road." My reply there is "that's what Gaia is for " I just need to see if Gaia supports Android Auto.

If you need some pics or have some questions I can wonder out to the car and double check but it all seems pretty easy to me.