I've had Spidertrax 1.25" spacers on my truck for almost 3 years now. They are on there purely for aesthetics. I don't have any issues in the front of the fender due to the high-clearance cut, but I did need to do a BMC and occasionally the tire will get up into the area of the pinch weld at the rear of the fender. I have lost the plastic trim piece that covers the pinch weld several times and ended up notching it so the tire clears. My tires are about 2" wider than yours tho.
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2017 TRD ORP KDSS IG
Dobinsons IMS w/ 314/325 Coils - JBA UCAs - Durobumps - Firestone 4108
DRKDSS Disconnect Switch - Treaty Oak KDSS Spacers - Eimkeith PCK
SSO Roof Rack - SSO Sliders - SSO Slimline - Smittybilt X20 10k - RCI Skids
TRD Pro Wheels - Spidertrax Spacers - Mickey Thompson Baja Boss A/T 255/85 R17