Slightly different perspective. I went from a 2004 4Runner SR5 to a 2013 GX460 Base.

Some things are night and day different obviously. The extra torque from the v8 was instantly noticeable, though the drive-by-wire pedal tuning is very weak-sauce on the GX460. I know that there are products on the market for this (Pedal Commander, etc.), but I found I got used to it anyway. Also, I only found this out right before I bought it, but a GX requires premium fuel. If you're a cheapskate like me, that might sting a bit. It'll run on 87, but the decrease in power and mileage isn't worth doing so.

As for the infotainment, I had a Pioneer head unit in my old 4Runner that had some nice features including a dedicated Pandora app, but I can't have any of that in the GX due to the integrated head unit from the 1830's. Your options for A/C is to set it to auto (which works well actually) or to go into a soft menu on the headunit to adjust the fan speed. No physical dials or switches for the fan speed.

It's a wash on the rear door. The swing out is weird, but the old hatch on the 4Runner took too much effort to close in my opinion. I think I rolled the rear window down maybe twice in the 5 years I had the truck.

Rear space is MUCH NARROWER in the GX. I was surprised by this once I measured. I had made a bike rack for the 4Runner (just a board with a couple of fork mounts screwed to it that clamped onto the rear tie-downs). Just to see what I would need to replicate it on the GX, I tried to put it in the GX to measure the new cutouts for the rear hooks and the board wouldn't fit across the back at all. A full 8" too long. The bikes wouldn't fit in the GX at all. I'd have to remove the handlebars and put them right next to each other for them to fit.

That said, EVERYTHING ELSE about the GX is superior. The v8, the 6 speed auto, the all-time 4WD with lockable center torsen diff, the leather interior with heated and cooled seats, the auto sensing wipers, you name it.