Well, in terms of tires, getting a mud tire for you, is out of the question. (In my opinion)
I think a good all-terrain tire is all you need. With all-terrain tires, their really not
great at anything, but their
good at everything. Also, if you want to take your truck off-road a little, then you will be aided with some tread, instead of a radial design. As well, an all-terrain tire will be friendly on the interstate, whereas a mud tire would impair your mileage, and there is no need for all that.
I would recommend:
1) Goodyear Wrangler Duratracs (Durable, light on truck, quieter)
2) Toyo Open Country A/T (Durable, somewhat aggressive A/T, quiet)
3) Mickey Thompson Baja MTZ Radials (More Durable, light on truck, quiet)
4) BFGoodrich KM2 A/T (quiet, most durable, not so light)
As for the wheels, I'm not sure. I have always had 16" five stars on this truck. I would assume you could fit 265-75R16s under there. But I do not know if it will lift you at all.
265-75R16s come to = 31.6"-10.4" R16
The easiest and most common lift here, is the runningboard lift
It's where you take your runningboards off, it gives the appearance of a higher 4Runner.. That's all I've done to my truck. People actually think I've lifted it.