Those tires should fit the rim fine (depending on what rims you have), you may do some searching and make sure that you won't have any fender rubbing anywhere else though. Just look at other peoples builds, find something you like, take some notes on their setup, then go from there. I'm running a 265/75R16 tire with a 2" lift now and I love it for an on and off road setup. I'm kinda partial to a more narrow tire myself (if they're available in the size I want), I don't see a big benefit to a wide tire unless I'm driving in sand. I still have some power to accelerate fairly well, not sure if that would be the case if I went to a bigger tire without re-gearing. Something to think about. This is a site I go to sometimes for tire calculations...
Tire Size Calculator
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2002 4Runner Sport Edition-285/75R16 Duratracs, OME suspension, TRD wheels, Shrockworks front/rear bumpers, White Knuckle sliders, etc.