i was running the factory jbl w/ the 6 in dash cd changer and installed an amp for 2 10 inch subs. i used a PAC Trunk-LOC line output converter with a built in remote power switch.
most oem radios do not have a remote power and causes the owner to run a separate wire by tapping into a 12 volt ignition or accessory, this is where you get the hiss, whine, or electrical interferance. and if you run your remote wire to an ignition or accesory you might get a big "THUMP" sound when turning your car on and off. the PAC Trunk-LOC converter has a soft turn on and off which means it fades the power on and off so no "THUMP".
it's real easy to install and comes with all the instructions. i got mine from ebay for about $35.00 shipped. just type in PAC trunk-loc.
good luck!!!