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Moderate Drinking Associated with Structural Brain Changes
By Amy Orciari Herman
Edited by David G. Fairchild, MD, MPH, and Lorenzo Di Francesco, MD, FACP, FHM
Drinking several high-alcohol beers — or their equivalent — each week is associated with adverse changes to the brain's structure, suggests a study in The BMJ.
Some 530 U.K. adults regularly reported their alcohol intake and underwent cognitive function testing over 30 years. At the end of follow-up, participants underwent brain MRI.
Higher alcohol intake was associated with reduced gray matter density, hippocampal atrophy, and reduced white matter microstructural integrity. Greater consumption was also linked to reduced lexical fluency (i.e., information retrieval based on spelling). Alcohol's effects were dose-dependent, with negative effects emerging with 7–14 units per week (14 units are equivalent to 4 pints of strong beer or 5 large glasses of wine). Light drinking (1–7 units/week) didn't have a protective effect.
An editorialist says the results "strengthen the argument that drinking habits many regard as normal have adverse consequences for health. With publication of this paper, justification of 'moderate' drinking on the grounds of brain health becomes a little harder."
By Amy Orciari Herman
Edited by David G. Fairchild, MD, MPH, and Lorenzo Di Francesco, MD, FACP, FHM
Drinking several high-alcohol beers — or their equivalent — each week is associated with adverse changes to the brain's structure, suggests a study in The BMJ.
Some 530 U.K. adults regularly reported their alcohol intake and underwent cognitive function testing over 30 years. At the end of follow-up, participants underwent brain MRI.
Higher alcohol intake was associated with reduced gray matter density, hippocampal atrophy, and reduced white matter microstructural integrity. Greater consumption was also linked to reduced lexical fluency (i.e., information retrieval based on spelling). Alcohol's effects were dose-dependent, with negative effects emerging with 7–14 units per week (14 units are equivalent to 4 pints of strong beer or 5 large glasses of wine). Light drinking (1–7 units/week) didn't have a protective effect.
An editorialist says the results "strengthen the argument that drinking habits many regard as normal have adverse consequences for health. With publication of this paper, justification of 'moderate' drinking on the grounds of brain health becomes a little harder."
