All I can say from 1st hand experience (basically a "Blind Test" due to the mix-up at the tire shop) is that I absolutely detected the handling difference from C to E in the same model tire (KO) - and this was only a 8.2lb difference per tire! (double checked: 265/70/17/C KO = 45.2lbs; 265/70/17/E KO = 53.4lbs). So that's only a total of 32lbs difference for the set of 4 (I initially stated close to 36lbs).
It literally felt like my steering movements were amplified around 70-80MPH and I really didn't like it (additional inertia of this extra mass spinning from the 17"-31" diameter @ 70-80MPH). Changing lanes seemed overly-touchy at these speeds, and was immediately noticeable. Acceleration also seemed a bit more sluggish (actually noticed that as soon as I drove out of the Tire Shop!), and while I didn't scrutinize my MPG for the week I had the incorrect E's on, I know it went down some.
LT KO C's are plenty sufficient for moderate trailing IMO. I'm not a crawler and don't air-down much at all, so my first-hand observed drawbacks of the KO E's made it clear KO C's are a better fit for my truck and the way I use it...
Feel free to slap on 100lb tires and tear up the trails if that's your thing! You can see the rear of my T4R as I accelerate away from you at the light

You aren't raining on my C-Load parade in the least

I'll take your "ninny" label on every 110 mile round-trip excursion to work

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Like mentioned - Chose the tire that makes the most sense for you and your personal preferences and tolerance for compromise. KO E's were just too much of a compromise for how I use my truck.
I'm willing to compromise (over-spec/over-spend) to the KO LT C's and take the MPG hit, but I like the KO's handling MUCH better than the stock P-Metric Dunlops I traded in after a few thousand miles (handling improvement is worth the extra cost of the KO's and minor MPG hit - but this is a personal debate only the person spending cash will be able to make - not an absolute by any means).
I'm simply reporting my
real-world "Quasi Blind Test" experience as I felt it was appropriate to this thread. I doubt many others have had such a chance for a true "Blind" test like this (due to the mix-up at the Tire Shop).