Better to focus on finding a clean example with a well documented service history than it is to focus on 2005+ w/ VVTi. I originally wanted a VVTi model for the extra power but I wound up buying an '04 because the previous owner kept it in immaculate condition and maintained a file with the complete service history. BAM, sold. I've owned the truck for about two years now with zero regrets.
One other thing: The 2UZ engine is pretty "lazy". It's not a high revver; even the VVTi version has a sub-6000 redline which these days is pretty unheard of. It has no problem pulling the truck up to highway speeds without revving much beyond 2500-3000 and it does so very smoothly.