Its going to depend on a few factors;
-What are you doing with the vehicle (Mild Off-road, Heavy off-road use, only street driving, ect)
-Age & condition of the XREAS System
-Compotent removal and installation of the XREAS components. (Improper removal or installation can render the system useless.)
-Funding
The XREAS system is a great tool on-road it really firms up the 4Runner compared to a regular 4Runner. That said, its down right brutal and horrible off-road. I went off-roading with my stock suspension in my '04 Sport and it was a very harsh ride with not as much benefit as you see on-road.
The spacer lift and taller springs will affect suspension geometry and would best go with a new UCA to bring the alignment back within factory specifications. (The cheapest set of UCA are like $450 IIRC) Chances are they may increase wear on the XREAS system due to added stress of different spring rate and compression from the spacer lift, but most people seem to get by okay.
Condensed version; XREAS Good on Road when working, Off-road XREAS stock and/or lift bad.