I was told that this swap along with new injectors could really increase the HP and tourque . I was wondering if anyone ever heard of doing this. The throttle body would also have to be swapped.
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Yeah, not sure where that was heard, but I have not discovered that.
More to the answer of your question: it would be unusual if a manifold made for a 4.7 V8 Tundra would fit easily into a V8 4Runner. Now, people have done it, more commonly prior to Doug Thorley releasing their short runner exhaust headers for the V8 4Runners.
The two common problems (as I recall) with the Tundra manifolds were the steering shaft location being different on the 4Runner, and more challenging; the narrower frame configuration.
Unless you REALLY wanted long tubes and wanted to pay a premium to have them heavily modified to fit a 4Runner, it'd be easier to just to put the Doug Thorley's on.
As for the injectors, regardless of the injector size the ECU is still going to fight tooth and nail to attain its programmed A/F ratios. Adding bigger injectors won't change the tuning at all because the ECU is waaaaay smarter than that. It would just run larger injectors as a lower duty cycle. Note that if installed manifolds allowed more air to move, there's plenty of headroom in the stock injectors for a small change like that.
Supposedly the 2UZ-FE ECU is pretty good at figuring out when it's being bamboozled... and send the correction factors of piggy back devices through the roof as the ECU and the piggy-back wrestle for control. Hence, there's very few tuning devices that list the 2UZ-FE as supported... let alone the 4Runner specifically.
The cross over pipe is probably just as detrimental to power as the headers are. However, I noticed a drop in bottom end torque after switching to the Doug Thorleys. I mean, now I make ~80% of peak torque at ~1800RPM instead of... like... idle. Which wasn't that useful anyway.