toto said:Yes, it would affect MPG.
But know that just because the A/C light is on doesn't mean the compressor is running. If it's near or below freezing outside, it can't run and the computer won't try. In Auto mode, the A/C light means that the A/C is "enabled" if the computer wants it. Usually the computer does want it, though, as a dehumidifier in either warm or cool weather.
The air conditioning does not work if the outside temperature is lowered down to around 0 C (32 F).
If the system is used for ventilation, heating in dry weather or removing frost or exterior fog on the windshield, turn the air conditioning off once it is no longer required. This will improve fuel economy. The air conditioning can be used for year