It may affect electronics like ABS. Mechanically, it wouldn't affect 2WD and on a full time 4WD, wear on the center diff is debateable since the difference is small.
well right now im running a spare on my back right tire, and on the back left tire its a 265/70/16, which is correct size, but somehow the company/ brand that made the tire made it a little too small, which irriates me, so i wanted 2 used tires in the back, there was this guy on craigslist selling 2 bfg a/t for $80 with over 50 percent tread, but the size was 265/75. so i was gunna get those , and in the future find 2 tires for the front the same size and treadwear