I know this thread has been sitting for a while, but I just figured I would fire it back up with my personal experience with a 3.0 V6. I had an '88 Xtra Cab with the 3.0, and in the early 90's, I did exactly what is being talked about here. I removed the crossover pipe, and ran 2" pipes from the stock exhaust manifolds all the way back with glasspack mufflers (Cherry Bomb I beleive) and resonator tips with NO cats.
I had a friend who was working at a Toyota Dealership at the time as a mechanic, and he kept telling me that sooner or later I was going to get a blown head gasket as he saw first hand that many of the V6's that came into the dealership for this very reason. I did this exhaust mod at about 40,000 miles, and never had a head gasket issue till the day the truck was stolen with 220,000 miles. That's gotta say something!
Yes, it did give a bit more power, but it really helped out the gas mileage. I was running 36" Super Swampers, 5.29 gears, and still managed to get 19-20 MPG average with about 22 MPG highway. Could probably been even better had I gone with a set of headers, but why? Sure, it was a bit loud under load... but at cuising speed and idle, it was fine. I guess it was the volume that may have taught me to baby it up through the gears to allow this kind of milage... who knows??
Just offering my $.02