No problems at all , BUT it does depend on your of road driving , if your running the baja I would not recommend it ...lol,
I unfortunately do not have place like Colorado, Utah , ect.... at my disposal , but mt 4R id my DD and act's as my expedition vehicle here , I take it through pretty much every thing ( with in reason ) hiils , forest trails , mud , rocks , water and with proper slow driving , paying attention , a nice set of AT tires I've been amazed at what the 4R is capable of in stock form. My only mods are an AT upsized tire. Give me a hole half inch extra ground clearance , but I'll take what I can get.
50K miles of driving someplace I shouldn't be with no issues. Take it slow , be logical ....... good to go.
Oh , tires are very important.