I averaged about 16-17 mpg for the majority of my trip from California to Kansas in my 4WD, with a couple of tanks hitting 20. As long as you keep the speed under 70 or so, your mileage won't be bad. I spent most of the trip on smaller highways instead of interstates, and that really seemed to help. As soon as I hit Kansas I didn't have any other options, and going 75-80 dropped my mileage down to about 12-13 mpg.
Not worth the savings or the effort imo. If you want to do it right, buy and install a set of manual hubs. They may not pay for themselves this trip, but if you do a lot of highway and other 2WD driving, they'll probably pay for themselves eventually, if not in fuel, then at least in reduced wear on your front drive components. I regularly see them on ebay for $100-150.