Best way: trade it for a car
Sorry, no other way to economically really do it. Full tune-up will help. Smaller, lighter wheels. Smaller tires. Adjust driving style. Lower the car. Replace front hubs with manual locking hubs. Pull off A/C belt.
In the end, you'll spend much more money trying to get better gas mileage than you would of spent in gas anyways. If you're hurting that bad, then either, you need to get a different (or another) vehicle that gets significantly better mpg or driver less.