I would recommend not airing up your tires. Stock is 32 and high tire pressure will effect your handling. If you start out at sea level at cooler temperatures and then travel to higher elevation and temperatures (like I normally do), your tire pressures could go quite high, and cause problems for your tires. I aired up to 34 starting many of my journeys and would generally notice that as I went up in elevation handling would suffer and would generally end up airing down, finding that my pressures were excessively high. After airing down a bit to closer to stockish pressures(~34-35 with hot tires) decent handling would return. My current Michelin tires have developed splits on the sidewalls and I think too high pressures and temps were the cause. I would be surprised if the .5mpg you saved would be worthwhile. (I also remember Gus's garage on motortrend saying basically the same thing). If you really want to get better mpg drop your speed to 62 mph and cruise control it. The difference between 80 and 60 is about 4 mpg or so from my experiences, 16 mpg at 80 and high 19-21 for 60. I once got 24 mpg and I have no idea why, slower speeds, 85 octane, a huge tail wind, downhill, I have no clue what I did that created the difference.
You might want to grab a cheap code reader before your road trip so if you pop a code in the middle of yellowstone national park, on a sunday, 100 miles from the next town, you can figure out for yourself if it's serious problem or not. Yes that happened to me

Turned out to be a 2nd o2 sensor smog crap issue, but at the time I was worried it was going to leave me stranded.
BTW if you have time to highway 1 it, do it!

There are some really scenic areas on it and nice twisty roads. 4runners no sports car, but it does reasonably well playing wanna-be-sportscar.