I have used it on a Rodeo with about 80K on it. Good stuff.
You basically disconnect the big vacuum hose from the brake booster. When disconnected, you will feel a huge amount of vacuum with the engine running.
Take your time and slowly pour the Seafoam into the hose. it will actually suck it in.
You will get a very impressive smoke plume from the exhaust from all the crap being burned off.
Shut the engine off and let some of the Seafoam that got sucked in sit for awhile, maybe 15 min.
Restart engine and be ready for another smoke plume.
Take the vehicle out and bury the gas pedal a few times.
Should run a lot better and smoother afterwards.
BTW - I did this just before an oil change and new plugs, don't know if thats necessary though.