All good, true and valid points above.
Got mine changed out today at 107,500k mies. Had 8 NGK IFR6A-11s in there. I don't think the PO ever had them swapped so I believe they were the factory plugs. They looked fine. Was a bit surprised to find 8 NGKs in there. Maybe only the V6 had half NGK half Denso?
I thought the Denso were stock that's why I went with the Denso SKR2011, guess not. They were recommended in the manual though. I've used NGK on cars in the past and have never had an issue. No big deal. I'm sure bth are fine plugs. Happy with my choice so far.
FYI- the original plugs are no longer available and have been replaced with NGK IFR6T-11. No clue what the difference may be.
The spark plug job wasn't bad. Just be careful pulling the plug clips (I used a plastic spudger tool to help pull the plastic tab up on the clip. I either lost one of the round rubber O-Ring grommets that go between the coil pack and the cylinder head, or it was missing from the factory. Don't lose one! The only way to buy one from Toyota is as part of the entire coil pack assembly - $115! Thankfully I found a local junkyard with one and pulled it off a highlander coil pack (exact same O-Ring). They just let me have it, but what a pain.
And be gentle tightening up the plugs. When I was 20 I over tightened a spark plug, stripped the hole and had to re-tap it. That doesn't always work so I was lucky. I torqued mine to about 16 lb ft. That's always my big fear when doing plugs. Breaking something else.
It's always a pain getting the spark plug socket off the new plug once it's tightened so some folks just use a deep socket. Your choice.
Have different length socket extenders if doing a V8. Master cylinder, air box and various vacuum hoses can be easily overcome obstacles.
I changed the oil while I was at it. Had to buy yet another end cap oil filter 'socket' tool.
I was going to clean the throttle body but don't like doing too many things to an engine at once. If something goes awry afterwards it's helpful to know which job caused the change. Will probably clean the TB in a month or so when I change the diff and transfer case fluids.
Have fun, be patient and good luck!