I've seen them go onto lots of different vehicles (5). Certain vehicles (some small-block Chevys) do respond to them. Most vehicles don't. It seems the more advanced the fuel injection system the less they help. I tried one on my Nissan Titan and notice a very minor improvement in the initial throttle response, VERY MINOR. As far as MPG is concerned, I got nothing.
What did make a difference was bypassing the throttle body's coolant passage. On the Nissan (I haven't looked at the T4R to even know), they ran a small amount of coolant through the throttle body to stabilize the temp in an effort to make the drivability more consistent and avoid icing. When I bypassed that coolant line it definitely performed a touch better and I picked up .5mpg. Now, keep in mind I live in Florida, I'm not sure I would do this if I lived in a colder climate, especially a cold, damp climate.
I tell this story because the Titan had current design fuel injection and a modern engine management, as does our T4R's.
Good Luck :cheers: