At 70mph, stock gearing and tire size in 5th gear with torque converter locked, 1988rpm.
70mph 4.56 gears and stock tires size 5th gear tc locked = 2430rpm.
70mph 4.56 gears and 32.8 tire = 2322 rpm
70mph 4.56 gears and 34" tire = 2259 rpm
Where I found it to be an issue is higher speeds and when you drop into 4th gear with 4.56.
80mph stock ratio and tires= 2253
80mph 4.56 and 32.8 tire = 2653
75mph 4th gear all stock = 2776
75mph 4th gear 32.6 tire = 3503
Now - what matters with this in fuel economy is the thermal efficiency at power and rpm.
This is the newer Toyota v6 GR engines. And what's overlaid here is the new atkinson cycle efficiency vs the old one. What's really important is how much the new engine expands the efficiency RPM ranges. But if you look at the older map underneath - it's still the 3.5 that's efficient at higher rpms. So it's still not totally representative. BUT with all those conditions, what you'll see is that the efficiency likely in ours drops off a pretty major efficiency cliff when you get beyond 2300 or so rpms. In our case I think it's really more like 21-2200 rpms is where that decline happens. By 3k rpms it's dropping very fast.
That's why people who are in areas typically driving at 80mph probably see a much greater mpg hit than people who are driving at 65mph most of the time. It's not just the higher wind resistance. It's that the engine is being pushed outside of it's thermal efficiency range.
If we had a good map for the 1GR (I'm not aware of anywhere to find one), then we could probably estimate pretty closely exactly what would happen with any gearing and/or tire combo.