Man, I would totally love to join you, but I've been doing some restoration work on my 2nd Gen.
If you're coming from PA, I would start in Cumberland. That's where I started when I drove over from Delmarva. This trip is such a good route...
I would recommend going when it's dryest so you can do the river crossings. Closer to spring, they're usually too high.
Bring some paper maps, and preplan some alternative camp sites before you go. There is no cell coverage at all as you get further south, so it isn't easy to make changes on the fly.
If you have the time, I would take a trip over to the New River Gorge National Park if you haven't been there before. It's a little over an hour from Lake Moomaw at the southern end of the route.
Good luck, and have fun!!!