if they aren't clogged, you are talking probably under 5 hp gain. You wont be changing anything in the ecu to take advantage of the changes you make, but im sure it will have a nice annoying drone on the highway.
what would produce the most power?
1) supercharger
and then wayyyy down the line
2) headers and a freeflowing exhaust
3) normal engine maintenance
4) a stiff tailwind
5) stripping the interior
6) maybe removing the cat, maybe