2006 V6 SR5, just surpassed 205K.
Purchased a few months ago at 198K and turned her out as a hard commuter (to/from Manhattan 5 days a week). Needed a few minor things when I bought her (leaky front shocks, torn cv boots, destroyed catback, etc).
Definitely want at LEAST 500K out of her, so I started a fairly intense preventative maintenance program immediately: all new fluids (incl. tranny "flush"), filters, new catback, 4 new tires, various headlight bulbs, new wheel hubs and axle half shafts (took me 2 days!), cleaned throttle and MAF.
Just noticed pink crusty leak on side of radiator, so ordered all parts necessary for coolant system refurb (radiator, thermostat, water pump, belt, pulleys, etc). Planning on replacing front struts/end links (tore 'em when I installed axles)/sway bushings, as well as rear shocks. Gonna do pads and rotors on all 4 corners when it warms up a bit.
After that, she'll be good as new! LOVE this truck!