Well, the 4runner is a different class to the Highlander and Rav4. If you get down to the nitty gritty...all the Highlander and and Rav4 are, in a sense...a bloated station wagon with high ground clearance, in my opinion...you won't find one rolling up the Rubicon trail...
I mean if you take the Sienna and chop off 6-8 inches from the floorpan, jack up the suspension and put bigger wheels on it...you have the Highlander.
Highlander/Rav4 are car/minivan based 'SUVs'. The 4Runner/Sequoia and LC are 'truck based' SUVs meaning that one time, they shared components with trucks...and maybe still do.
There are very few 'designed as SUV from ground up' vehicles out there...Rovers? G-class? XJ (Jeep Cherokee no longer made)...
In the truck based SUVs...the 4runner moved to midsize class (Explorer, Pathfinder, etc.) in the 4th gen...before that, it was in the compact class.
I believe both the LC and Sequoia are full size class like the Suburban/Tahoe.
In the car based SUVs...the Highlander is midsize class and Rav4 is the compact class (i.e., Escape, X3, etc.).
I don't believe Toyota has any thing in the car based full size class...like Chevy Transverse.
Oh, you might have heard car/minivan based SUVs be referred to as 'crossovers'...which I think is 'stupid'.