GM, Dodge, Honda to name a few. Believe it or not, Cadillac was one of the first (if not the first, I don't know) to try cylinder deactivation to save on fuel.
They actually used the term 8-6-4 as a selling point. But it was a huge failure.
We had family friends who had them and they had nothing but problems with them.
From wiki...
For 1981 Cadillac introduced a new engine that would become notorious for its reliability problems (with the electronics, not the robust mechanical design), the V8-6-4 (L62). The L61 had not provided a significant improvement in the company's CAFE numbers, so Cadillac and Eaton Corporation devised a cylinder deactivation system called Modulated Displacement that would shut off two or four cylinders in low-load conditions such as highway cruising, then reactivate them when more power was needed. When deactivated, solenoids mounted to those cylinders' rocker-arm studs would disengage the fulcrums, allowing the rockers to "float" and leave the valves closed despite the continued action of the pushrods. These engines are easily identified by their rocker covers, which each have elevated sections over 2 cylinders with electrical connectors on top. With the valves closed the cylinders acted as air-springs, which both eliminated the feel of "missing" and kept the cylinders warm for instant combustion upon reactivation. Simultaneously, the engine control module would reduce the amount of fuel metered through the TBI unit. On the dashboard, an "MPG Sentinel" digital display could show the number of cylinders in operation, average or current fuel consumption (in miles per gallon), or estimated range based on the amount of fuel remaining in the tank and the average mileage since the last reset.[5]
Another rare and advanced feature introduced with DFI was Cadillac's truly "on-board" diagnostics. For mechanics who had to deal with the 368's, the cars contained diagnostics that did not require the use of special external computer scan-tools. The new Electronic Climate Control display, along with the MPG Sentinel, provided on-board readout of any stored trouble codes, instantaneous readings from all the various engine sensors, forced cycling of the underhood solenoids and motors, and on the V8-6-4 motors, manual cylinder-pair control. The L62 produced 140 hp (104 kW) at 3800 rpm and 265 lbf·ft (359 N·m) at 1400 rpm. Cadillac hailed the L62 as a technological masterpiece, and made it standard equipment across the whole Cadillac line.
While cylinder deactivation would make a comeback some 20 years later with modern computing power (and using oil pressure to deactivate the valves by collapsing the lifters) Cadillac's 1981 V8-6-4 proved to have insurmountable engineering problems. The main issue was that the Engine Control Module simply lacked the robustness, programming and processing speed to efficiently manage the cylinder-deactivation under all load conditions. In the era before electronically operated EGR valves, the engineers also made an error in using a "back-pressure-type" EGR valve... While this early effort to match the vacuum-controlled EGR volume more accurately to the engine's load made sense in a 'normal' engine, it had the effect of causing pinging (detonation) problems in the V8-6-4 engine, because 4 cylinders operating under higher load needed more EGR, while they were actually producing less exhaust flow and therefore less back-pressure to operate the valve...
Off topic a little...