I was going from memory so 10" was a bit ambitious (hold the jokes...)
But looking at this picture I stole, that's a standard 7" double din screen. I think it would be possible to finesse an 8 or 9" screen in the standard aspect ratios, or possibly make the screen ultra-wide to cover the empty sides there. I'd much prefer that over a vertical screen that cuts out the HVAC knobs.
It would be cool to make it split screen, have the left side show Nav and the right side show sensor readouts. My current head unit plugs into the OBDII port and I can switch between Nav and sensors using the steering wheel controls, I would love to have them both up at the same time. Or you can have Nav on the left, music on the right, etc.