Maybe it wants you to update? Try unplugging your battery. This should reset the nav unit and hopefully at least allow you to access some settings. Since the radio is on the hot bus (always gets power), turning the truck off isn't enough to reset it.
I once f***ed up the update on my aftermarket indash nav and I was sure the arse had fallen out of her, but disconnecting the battery reset the unit back to normal.
It's a long shot but it's better than no shot