My 3rd generation 4R went 240k on the original plugs (until it was totalled), not to mention wires, fuel filter, etc. It was the everready bunny of vehicles!
Not that I'm advocating such treatment of any vehicle, but it never showed a mileage drop or any other affects. After 200k I was convinced that I was more likey to snap the plugs off rather than actually get them out, so I just left well enough alone. My buddy wanted to change them purely as a scientific experiment to see what was left of the electrodes, sort of like examining a peice of bread left out for a couple of weeks I guess!
I'm not tempting fate like that with the replacement - an '04 V6!