Yea, it means your engine is sealed. The engine pulls crankcase ventilation through the PCV(passenger side valve cover and the breather(drivers side valve cover) into the intake. By taking the cap off you created a vacuum leak in a sense.
left the cap on the valve cover and forgot to install. drove around for a few days and it never moved. sometimes i do it at work to see if i need to add more oil so i leave cap of and start the car.