I have owned a 5th generation 4Runner and recently test drove a Honda Pilot. I was very impressed with the ride and handling of the Pilot. It was very comfortable and the EX-L model has lots of nice interior creature comforts. The 3rd row has much more space than the 3rd row of the 4Runner. The stock stereo in the EX-L sounds tons better than the stock stereo in the 4Runner. There is lots of interior storage space but the downside for me is that I cannot stand my triathlon bike in the back of the Pilot with the front wheel off whereas in the 4Runner I can. The 2WD Pilot's fuel economy is rated at 18-25 (when I took an extended test drive I averaged 23 mpg combined city/hwy) whereas the 2WD SR5 4 Runner that I owned got real life 17 mpg around town and 21-22 mpg on highway. I did find the 4Runner to be a comfortable vehicle and it's towing capacity far exceeds the 2500 lb limit on a 2WD Pilot. I do like the power window on the rear hatch of the 4Runner. The one thing that I had a hard time overcoming on the Pilot is that it is a fugly vehicle from the side profile. Head on it looks good as does the rear but the side view leaves alot to be desired in aesthetics. If your wife has a minivan, why are you worried about 3rd row seating? If this is your vehicle, than I'd say screw the 3rd row seating in the 4Runner as others have said, it does take up unneccessary space in the rear cargo area. For me, it means being able to stand up my tri bike vs not being able to in models with the 3rd row seats folded down (the height from ceiling to floor is about 4 inches less in models with 3rd row seats vs those with the sliding cargo tray). We traded our 4Runner in for a Honda Odyssey as it didn't make much sense for us owning my FJ as well as a 4Runner. Now that my wife is all set in her new Odyssey Touring model, I have been considering trading my FJ in on a Trail Edition 4Runner. By the way, living in Florida, you will be fine with a 2WD 4Runner. They gave us $29,500 trade on the 4Runner and sold us the Odyssey at Invoice. My 4Runner was an SR5 with only options being convenience package and sliding cargo tray. Good luck in your decision.