well that depends on you, the driver.
i have the 2.5" OME on my 02 and 285's and i decided to regear because my rear diff was shot and it was only a few hundred more to go to 4.56's while it was open. if you have 4.10's then unless you notice a BIG difference ( you wont notice that big of one) then just leave them in until you decide you want a locker(s)