R134 auto are all quick disconnect fittings. All manifold sets that I'm aware of use 1/4" fitting hoses, some have 3/8 for faster vacuum on that port. If your referring to the little charging bottles from the auto store, I have no idea what fitting they are? Any size service port other than 1/4" would require an adapter to a standard 1/4" hose I am guessing. I'll check on my 4runner's service port tonight and see what is required to gauge up to the system. I think they manufactured these with different sizes to make the user aware of different refrigrations and the non licensed guy use to not be able to purchase the gas, untill these little bottles became avalible years ago.