Does the V6 have a center diff lock like the V8s do? If so, and you only replace 2 tires, then it may take a lot longer for the center diff lock to engage/disengage because the 2 axles are spinning at different speeds due to the different tire diameters. Also, if/when you drive in 4Hi, you may put a little more strain on the center diff, but since you have the V6 and can drive in 2Hi you can avoid that.
An alternative would be to buy a used tire of a similar diameter, or maybe have somebody shave down a new tire.