Lost 1MPG going from Nitto Terra Grappler 265\70\17 SL load @ 40lbs each to Toyo Open Country RT in 285\70\17 E load @ 60lbs each. Definitely can feel the sluggishness of the bigger\heavier tires even with the supercharger, but all this was to be expected. The supercharger definitely helps, and it can still go if I need it to. I feel like it's not that I can't get the lost mpg back with the bigger tires, but that it's more sensitive. I have to drive really conservatively to gain back the lost in efficiency, easier on highway\freeway speeds. Once I hit city traffic, the MPG drops quick. All in all, I think for me the benefits of going to larger tires out weigh the negatives