Do you notice the extra weight?
I have ran pretty much every type and ply offered throughout my 36 years of driving. I only run P rated now.
If I lived in the desert with lots of sharp rocks and thorns then I would run C rated so I would be more comfortable with low pressures. Never again E for me as there are too many cons and not enough pros. Never mind I had to get a tire patched yesterday after running over a nice socket head cap screw. I would rather get a patch once in a blue moon than never get a patch and suffer 60K miles of inefficiency and hard ride.