05 SR5 V6, owned since December 2004. 109k miles. I'm averaging 16-17k/year.
Major issues I've had so far include:
-90k: Leaking water pump. Cost me $350 parts/labor through a friend who had a discount at a Toyota dealership
-107k: Cracked radiator. Overheated, or barely overheated (was in the red and/or touched the line... hopefully I didn't do any damage). Replaced with a Koyo radiator and Toyota Red for $400 (toyota specialist) +$100 (toyota dealership) for the pressure test. I could have saved about $200 knowing how easy it is after watching the process.
Minor issues include:
-Battery. Switched it a month or 2 ago. Optima Yellow-Top.
-Springs/Shocks. Switched it out in May. Feels like I'm driving a brand new 4runner.
-Air Filter. I installed a K&N Air Filter a year ago, but I swapped it out for an OEM Filter at 105k miles. I didn't like it too much, but that's just me.