Interesting that I just came across this thread.
My girlfriend's 2004 4Runner has 208,000 miles on it and it ha been nearly flawless the entire time (except for that cracked dash thing which we had written off to age, but it looks like that will be taken care of!).
Recently, I drove it to pick up her grandkids and when I started it, I noticed a miss for a minute or two, then it cleared up and ran normally. I asked her if she had (A) ever noticed this and (B) ever had the spark plugs changed. We looked through her service records and it doesn't look like they ever have. Geez! Oh, and this is when she told me that the check engine light came on during her drive home from work, so she pulled in the AutoZone and had them run the diagnostics on it. All it turned up was #6 plug "not working properly". This was all good to know...

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So I bought the proper Denso plugs (Iridium, since they didn't have the copper ones) and installed them. Not too bad, except for the scary feeling of the old plugs backing out. But none of them galled and they all looked the same. Kinda brown with some age, but no oil on them. I used anti-seize compound on the new ones and finished the job easily (and a LOT easier than I thought it would be!). I disconnected the battery to clear the codes, cranked the 4Runner, and all seemed fine.
A week later, she said the check engine light came on again, but when I went to check it, the miss had come back and like last time, it went away after a minute or two. Also, the check engine light had gone off, which was odd.
Anyway, my point of the post is to inquire about something I read earlier. Is there a chance of a head gasket problem? I hope to change the plugs for trouble-shooting purposes early next week, so I'll know more then.
I guess all good things must come to an end. This 4Runner is still running and driving great. It has survived 3 grandkids, 4 road trips with us and them, and her daily commute to work for 10 years. It's the most impressive vehicle I've been around. I'm certain that with these kind of miles, some repairs are on the horizon. And since I just bought a new Nissan Armada I was looking for a 4Runner, But the deal on the Nissan was way too good to pass up. Basically took over some notes), I hope to take some of the load off of the 4Runner from now own.
Thanx for any insight.