The center diff should be unlocked, and it normally is unlocked unless you lock it.
If it's unlocked:
Handling in turns is neutral, and you'll have the best chance of going on the line you intend. VSC is active, so it will help correct if you start to spin out (turn too much when you want to go straight) and maybe if you start to understeer (not turn enough when you want to turn). VSC can brake individual wheels, so it's better than even an expert driver in some situations, but ultimately the tires still limit your traction.
With it locked:
The center diff can be locked by pressing the button with 4 wheels and an x in the middle. That turns off VSC, so you'll see a yellow center diff lock light and a yellow VSC off light on the instrument panel by the green 4WD light. With the center diff locked, both axles must turn at the same speed, so the vehicle will tend to understeer on slippery surfaces (goes straight when you are trying to turn). VSC is off, so it will not help you maintain control. Locked is good for not getting stuck on deep snow or steep hills.
The most important thing for driving on snow and ice is having good tires. Winter tires are best. If you don't have those, good all season tires with plenty of tread left are OK but not nearly as good. If you have less than 4/32" of tread depth on your tires, they won't be safe in the snow. Even more tread depth would be ideal since 4/32 is pushing it. Look up how to measure that with a coin.
Some people will inevitably disagree with me on locked vs unlocked, but I've tried it both ways in a snowy parking lot, and you can try it too if your 4runner isn't damaged. I found it much easier to maintain control with it unlocked.