It's funny because I've been driving a Durango (the V6 variety) as a rental for a couple of weeks now while my 4Runner gets some hail damage repaired and have thought about outlining the differences on a thread here.
I actually prefer Entune as it relates to both calling and sat radio. I always thought the satellite radio reception on the T4R was especially bad, but it is actually quite a bit worse on the Durango, randomly cutting out and losing signals in places the 4Runner had no problem. It also constantly thinks I want to make a handless call, presumably because it's easy to bump a switch on the steering wheel when turning. However, the onboard computer setup is pretty nifty - can check tire pressure, oil pressure, engine temperature, etc.
I've also learned how awesome keyless entry is, but must say that it is a bit quirky on the Durango, not always unlocking or locking when prompted. I also won't even mention the "gear selector dial" - that thing just doesn't feel right.
It actually drives quite nicely, with a really smooth transmission (I'm sure there is a price to be paid in terms of maintenance on this one). The V6 doesn't feel more powerful than the 4Runner, but it geared better so you can get that quick pickup in 1st gear.
So my summary is that it's a nice car to drive, but the features just don't feel as well-thought out as other vehicles I've driven. Knobs and switches in weird places, fickle electronic components like the keyless entry and voiceless calling.