TL;DR - Swapped from Michelin Defender LTX M/S to Pathfinder AT and am quite happy with the change.
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I'm not running a lift (yet) or custom wheel/tire sizes (still running 265/70-17), but I did just switch up tire brands and am thrilled with the results.
When I bought the T4R, it had Michelin LTX M/S tires, which I am quite familiar with and ran on my Grand Cherokee for years. I didn't have any issue with them except that they eventually started wearing faster than I thought they should (didn't even come close to manufacturer rating). Turns out the front-end desperately needed an alignment.
Anyway, as Michelins aren't cheap, I was looking for more affordable alternatives with a little more aggressive tread pattern for better off-road. I ended up getting a Pathfinder AT set from Discount Tire. I must say I am very impressed. I think the tires are actually quieter than the Michelin set and are wearing great (though it's hard to really compare since those tires were garbage after the alignment destroyed them). I really like the tread pattern as well. I'm about to give them their first Utah winter (the tires have the three-peak snow stamp on them), so we'll see how they go there. All in all, I don't see much reason to buy the more expensive tires after running on these for over six months.