You're over thinking it.
The difference is going to be hardly noticeable. Put in a fresh set of any plugs you choose and enjoy the ride. Don't like it? Plugs are easy to change anyhow on these. Chasing every ounce of power out of these is a long expensive battle. There are tons of guys on here with smaller pulleys, 7 injectors with hours of tuning, meth injection, turbo setups yadda yadda and they still want more juice.
My recommendation is to pick a stopping point, achieve it, and accept the results.
If your goal is the feel of Chevy V8 power, then you're going to need to put a Chevy V8 in your truck. Not saying a SC isn't worth it, as I would NEVER go back, but in my experience, it was just the little extra oooomf these engines need. Not a miracle fix. It's a heavy, bulky truck build for longevity.
That's my $.02 and good luck dude