Yep. Increased scrub radius will cause clearance issues. Lift unlikely to help. No idea why people add spacers for no reason at all. They add weight and increase points of failure, I don't see the upside.
Stance and street cred, bro! Added bonus, you get to throw debris all over the side of your truck.
Not sure if it's the same on the 4R, but using spacers when lowering a car was just a cheap band-aid to avoid buying wheels that had the correct offset for the application.